Drug interactions
Lonapegsomatropin + Midazolam
Severity: Minor
Lonapegsomatropin and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase CYP450-mediated clearance, which could slightly lower midazolam exposure. Clinical evidence for a relevant effect is limited.
What this interaction means in plain words
Lonapegsomatropin and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonapegsomatropin belongs to Endocrine; Midazolam belongs to Central Nervous System.
Why it happens
Possible induction of CYP3A4 activity by growth hormone; not well established.
What to do
No routine adjustment is needed; titrate midazolam to clinical effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lonapegsomatropin and Midazolam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Lonapegsomatropin with Midazolam?
MediHelp rates the interaction as minor. Lonapegsomatropin and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may increase CYP450-mediated clearance, which could slightly lower midazolam exposure. Clinical evidence for a relevant effect is limited.
How serious is the interaction between Lonapegsomatropin and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; titrate midazolam to clinical effect.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
