Drug interactions
Lonapegsomatropin + Saxagliptin
Severity: Moderate
Lonapegsomatropin and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone can reduce insulin sensitivity and raise blood glucose, working against saxagliptin. Patients with diabetes may need their antihyperglycemic treatment adjusted.
What this interaction means in plain words
Lonapegsomatropin and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonapegsomatropin belongs to Endocrine; Saxagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: growth hormone induces insulin resistance and counteracts glucose lowering.
What to do
Monitor blood glucose and HbA1c after starting or changing the dose of lonapegsomatropin, and increase antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lonapegsomatropin and Saxagliptin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Lonapegsomatropin with Saxagliptin?
MediHelp rates the interaction as moderate. Lonapegsomatropin and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone can reduce insulin sensitivity and raise blood glucose, working against saxagliptin. Patients with diabetes may need their antihyperglycemic treatment adjusted.
How serious is the interaction between Lonapegsomatropin and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing the dose of lonapegsomatropin, and increase antidiabetic therapy as needed.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
