Drug interactions
Lonapegsomatropin + Sirolimus
Severity: Minor
Lonapegsomatropin and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone can increase CYP450-mediated clearance, so sirolimus concentrations could fall. Lower exposure may reduce immunosuppression.
What this interaction means in plain words
Lonapegsomatropin and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonapegsomatropin belongs to Endocrine; Sirolimus belongs to Miscellaneous.
Why it happens
Growth hormone may induce CYP3A4 activity, increasing sirolimus metabolism.
What to do
Monitor sirolimus trough levels after lonapegsomatropin is started or its dose changed and increase the sirolimus dose if concentrations fall below target.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Lonapegsomatropin with Sirolimus?
MediHelp rates the interaction as minor. Lonapegsomatropin and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone can increase CYP450-mediated clearance, so sirolimus concentrations could fall. Lower exposure may reduce immunosuppression.
How serious is the interaction between Lonapegsomatropin and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels after lonapegsomatropin is started or its dose changed and increase the sirolimus dose if concentrations fall below target.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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