Drug interactions
Lonapegsomatropin + Tacrolimus
Severity: Minor
Lonapegsomatropin and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase CYP450-mediated clearance, which could lower tacrolimus levels. The evidence is limited and the effect is likely small.
What this interaction means in plain words
Lonapegsomatropin and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonapegsomatropin belongs to Endocrine; Tacrolimus belongs to Miscellaneous.
Why it happens
Possible induction of CYP3A4 activity by growth hormone increases tacrolimus metabolism.
What to do
Check tacrolimus trough levels after starting or changing the lonapegsomatropin dose, particularly in transplant recipients. Adjust the tacrolimus dose if levels fall below target.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Lonapegsomatropin with Tacrolimus?
MediHelp rates the interaction as minor. Lonapegsomatropin and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may increase CYP450-mediated clearance, which could lower tacrolimus levels. The evidence is limited and the effect is likely small.
How serious is the interaction between Lonapegsomatropin and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check tacrolimus trough levels after starting or changing the lonapegsomatropin dose, particularly in transplant recipients. Adjust the tacrolimus dose if levels fall below target.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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