Drug interactions
Loperamide + Nefazodone
Severity: Moderate
Loperamide and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a potent CYP3A4 inhibitor and may also inhibit P-gp, which can raise loperamide concentrations. Higher exposure increases the risk of CNS effects and QT prolongation.
What this interaction means in plain words
Loperamide and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 metabolism and P-gp efflux of loperamide.
What to do
Use the lowest effective loperamide dose for the shortest time and monitor for sedation, constipation and palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Frequently asked questions
Can I take Loperamide with Nefazodone?
MediHelp rates the interaction as moderate. Loperamide and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a potent CYP3A4 inhibitor and may also inhibit P-gp, which can raise loperamide concentrations. Higher exposure increases the risk of CNS effects and QT prolongation.
How serious is the interaction between Loperamide and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective loperamide dose for the shortest time and monitor for sedation, constipation and palpitations.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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