Drug interactions
Loperamide + Rifampin
Severity: Minor
Loperamide and Rifampin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces CYP3A4, CYP2C8 and P-glycoprotein and substantially lowers loperamide plasma concentrations. The antidiarrheal effect may be reduced, though central opioid effects are also diminished.
What this interaction means in plain words
Loperamide and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP enzymes and P-gp increases loperamide clearance.
What to do
Monitor stool frequency and adjust loperamide within labeled maximum doses if control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loperamide
Frequently asked questions
Can I take Loperamide with Rifampin?
MediHelp rates the interaction as minor. Loperamide and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifampin induces CYP3A4, CYP2C8 and P-glycoprotein and substantially lowers loperamide plasma concentrations. The antidiarrheal effect may be reduced, though central opioid effects are also diminished.
How serious is the interaction between Loperamide and Rifampin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor stool frequency and adjust loperamide within labeled maximum doses if control is inadequate.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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