Drug interactions
Lorazepam + Maprotiline
Severity: Moderate
Lorazepam and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline is a sedating tetracyclic antidepressant, and with lorazepam it increases drowsiness and psychomotor impairment. Maprotiline also lowers the seizure threshold, which is relevant if benzodiazepines are withdrawn abruptly.
What this interaction means in plain words
Lorazepam and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorazepam belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and the antihistaminic and anticholinergic effects of maprotiline.
What to do
Monitor for oversedation, and counsel on driving and alcohol. Taper lorazepam gradually rather than stopping suddenly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Lorazepam with Maprotiline?
MediHelp rates the interaction as moderate. Lorazepam and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline is a sedating tetracyclic antidepressant, and with lorazepam it increases drowsiness and psychomotor impairment. Maprotiline also lowers the seizure threshold, which is relevant if benzodiazepines are withdrawn abruptly.
How serious is the interaction between Lorazepam and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, and counsel on driving and alcohol. Taper lorazepam gradually rather than stopping suddenly.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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