Drug interactions
Lorazepam + Methocarbamol
Severity: Moderate
Lorazepam and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorazepam is a benzodiazepine, and methocarbamol adds central depressant effects. Together they can cause marked sedation, impaired coordination and, with higher doses or other depressants, respiratory depression.
What this interaction means in plain words
Lorazepam and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorazepam belongs to Central Nervous System; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive CNS depression via GABA-A potentiation by the benzodiazepine and central muscle relaxant activity of methocarbamol.
What to do
Use the lowest effective doses and monitor for oversedation and respiratory depression, especially in older or frail patients. Advise against alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Other interactions of Lorazepam
Frequently asked questions
Can I take Lorazepam with Methocarbamol?
MediHelp rates the interaction as moderate. Lorazepam and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorazepam is a benzodiazepine, and methocarbamol adds central depressant effects. Together they can cause marked sedation, impaired coordination and, with higher doses or other depressants, respiratory depression.
How serious is the interaction between Lorazepam and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and respiratory depression, especially in older or frail patients. Advise against alcohol and driving.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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