Drug interactions
Lorazepam + Oliceridine
Severity: Major
Lorazepam and Oliceridine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with benzodiazepines carry a boxed warning for profound sedation, respiratory depression, coma and death. Oliceridine is a potent intravenous opioid and the risk applies to it alongside lorazepam.
What this interaction means in plain words
Lorazepam and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lorazepam belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression through opioid receptor agonism and GABA-A potentiation.
What to do
Reserve the combination for patients with no adequate alternatives, using the lowest doses and shortest duration. Monitor continuously for sedation and respiratory depression, with naloxone available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Lorazepam
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Lorazepam with Oliceridine?
MediHelp rates the interaction as major. Lorazepam and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with benzodiazepines carry a boxed warning for profound sedation, respiratory depression, coma and death. Oliceridine is a potent intravenous opioid and the risk applies to it alongside lorazepam.
How serious is the interaction between Lorazepam and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients with no adequate alternatives, using the lowest doses and shortest duration. Monitor continuously for sedation and respiratory depression, with naloxone available.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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