Drug interactions
Lorazepam + Oxymorphone
Severity: Major
Lorazepam and Oxymorphone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent opioids and benzodiazepines can cause profound sedation, respiratory depression, coma and death, and this risk is covered by a boxed warning. The risk is greatest at higher doses and in elderly or respiratory-compromised patients.
What this interaction means in plain words
Lorazepam and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lorazepam belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression via opioid receptors and GABA-A potentiation.
What to do
Avoid the combination where possible; if needed, use the lowest doses for the shortest duration and monitor closely for respiratory depression and sedation. Counsel patients and caregivers about warning signs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Lorazepam
Frequently asked questions
Can I take Lorazepam with Oxymorphone?
MediHelp rates the interaction as major. Lorazepam and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent opioids and benzodiazepines can cause profound sedation, respiratory depression, coma and death, and this risk is covered by a boxed warning. The risk is greatest at higher doses and in elderly or respiratory-compromised patients.
How serious is the interaction between Lorazepam and Oxymorphone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if needed, use the lowest doses for the shortest duration and monitor closely for respiratory depression and sedation. Counsel patients and caregivers about warning signs.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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