Drug interactions
Lorazepam + Quetiapine
Severity: Moderate
Lorazepam and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating, and together they can cause pronounced drowsiness, dizziness, and orthostatic hypotension. Falls and impaired alertness are the main risks, particularly in older adults.
What this interaction means in plain words
Lorazepam and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorazepam belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and quetiapine's antihistaminic and alpha-1 blocking activity.
What to do
Monitor sedation and orthostatic blood pressure, and use the lowest effective doses. Counsel patients on driving and fall precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Lorazepam with Quetiapine?
MediHelp rates the interaction as moderate. Lorazepam and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating, and together they can cause pronounced drowsiness, dizziness, and orthostatic hypotension. Falls and impaired alertness are the main risks, particularly in older adults.
How serious is the interaction between Lorazepam and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure, and use the lowest effective doses. Counsel patients on driving and fall precautions.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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