Drug interactions
Lorazepam + Ramelteon
Severity: Minor
Lorazepam and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramelteon has mild sedative properties, and combined use with lorazepam may add to next-day drowsiness. Ramelteon is not known to cause significant respiratory depression, so the added effect is usually modest.
What this interaction means in plain words
Lorazepam and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lorazepam belongs to Central Nervous System; Ramelteon belongs to Central Nervous System.
Why it happens
Mild additive sedation via melatonin MT1/MT2 agonism plus GABA-A potentiation.
What to do
No dose change is generally required; ask about daytime drowsiness and counsel on avoiding driving if impaired.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lorazepam
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Lorazepam with Ramelteon?
MediHelp rates the interaction as minor. Lorazepam and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ramelteon has mild sedative properties, and combined use with lorazepam may add to next-day drowsiness. Ramelteon is not known to cause significant respiratory depression, so the added effect is usually modest.
How serious is the interaction between Lorazepam and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; ask about daytime drowsiness and counsel on avoiding driving if impaired.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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