Drug interactions
Lorazepam + Ziprasidone
Severity: Moderate
Lorazepam and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together they can increase drowsiness and dizziness, and injectable forms given close together may produce excessive sedation. Ziprasidone's QT effect is not altered by lorazepam, so the concern is mainly additive CNS depression.
What this interaction means in plain words
Lorazepam and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorazepam belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and ziprasidone's central receptor antagonism.
What to do
Monitor sedation and vital signs, especially after intramuscular dosing. Counsel patients on avoiding driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Lorazepam with Ziprasidone?
MediHelp rates the interaction as moderate. Lorazepam and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Together they can increase drowsiness and dizziness, and injectable forms given close together may produce excessive sedation. Ziprasidone's QT effect is not altered by lorazepam, so the concern is mainly additive CNS depression.
How serious is the interaction between Lorazepam and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and vital signs, especially after intramuscular dosing. Counsel patients on avoiding driving until the response is known.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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