Drug interactions
Lorcaserin + Lurasidone
Severity: Moderate
Lorcaserin and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin is a serotonin 5-HT2C agonist, and combining it with a serotonergic antipsychotic may increase the risk of serotonin syndrome. Lorcaserin has been withdrawn from the US market, which limits current relevance. Serotonin 5-HT2C agonism may also oppose the effects of lurasidone.
What this interaction means in plain words
Lorcaserin and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects with possible pharmacodynamic opposition at 5-HT2C and dopamine pathways.
What to do
Monitor for signs of serotonin syndrome such as agitation, tremor, hyperthermia and clonus, or neuroleptic malignant syndrome. Consider an alternative to lorcaserin if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lorcaserin with Lurasidone?
MediHelp rates the interaction as moderate. Lorcaserin and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorcaserin is a serotonin 5-HT2C agonist, and combining it with a serotonergic antipsychotic may increase the risk of serotonin syndrome. Lorcaserin has been withdrawn from the US market, which limits current relevance. Serotonin 5-HT2C agonism may also oppose the effects of lurasidone.
How serious is the interaction between Lorcaserin and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome such as agitation, tremor, hyperthermia and clonus, or neuroleptic malignant syndrome. Consider an alternative to lorcaserin if symptoms occur.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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