Drug interactions
Lorcaserin + Metoprolol
Severity: Minor
Lorcaserin and Metoprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin is a weak inhibitor of CYP2D6, the main enzyme that clears metoprolol. Metoprolol exposure may rise modestly, which could produce more bradycardia or hypotension. Lorcaserin has been withdrawn from many markets.
What this interaction means in plain words
Lorcaserin and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP2D6-mediated metoprolol metabolism by lorcaserin.
What to do
Monitor heart rate and blood pressure after lorcaserin is started. Lower the metoprolol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Lorcaserin with Metoprolol?
MediHelp rates the interaction as minor. Lorcaserin and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lorcaserin is a weak inhibitor of CYP2D6, the main enzyme that clears metoprolol. Metoprolol exposure may rise modestly, which could produce more bradycardia or hypotension. Lorcaserin has been withdrawn from many markets.
How serious is the interaction between Lorcaserin and Metoprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after lorcaserin is started. Lower the metoprolol dose if bradycardia or hypotension develops.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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