Drug interactions
Lorcaserin + Zolmitriptan
Severity: Moderate
Lorcaserin and Zolmitriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance serotonergic activity, so combining them could lead to serotonin syndrome with agitation, tremor, hyperthermia and neuromuscular hyperreactivity. Documented cases are rare, but the labeling for both drug classes cautions about the combination. Lorcaserin has been withdrawn from the US market.
What this interaction means in plain words
Lorcaserin and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from 5-HT2C agonism by lorcaserin and 5-HT1B/1D agonism by the triptan.
What to do
If combined, watch for signs of serotonin syndrome, especially after starting or raising doses. Stop one agent if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Lorcaserin with Zolmitriptan?
MediHelp rates the interaction as moderate. Lorcaserin and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs enhance serotonergic activity, so combining them could lead to serotonin syndrome with agitation, tremor, hyperthermia and neuromuscular hyperreactivity. Documented cases are rare, but the labeling for both drug classes cautions about the combination. Lorcaserin has been withdrawn from the US market.
How serious is the interaction between Lorcaserin and Zolmitriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If combined, watch for signs of serotonin syndrome, especially after starting or raising doses. Stop one agent if symptoms occur.
What other medicines interact with Zolmitriptan?
MediHelp also lists interactions of Zolmitriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Zolmitriptan page.
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