Drug interactions
Lorlatinib + Lurbinectedin
Severity: Moderate
Lorlatinib and Lurbinectedin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib may reduce lurbinectedin exposure by inducing CYP3A4, potentially reducing antitumor efficacy.
What this interaction means in plain words
Lorlatinib and Lurbinectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Lurbinectedin belongs to Oncology.
Why it happens
CYP3A4 induction by lorlatinib increases lurbinectedin clearance.
What to do
Avoid combination if feasible and monitor tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Lurbinectedin
Frequently asked questions
Can I take Lorlatinib with Lurbinectedin?
MediHelp rates the interaction as moderate. Lorlatinib and Lurbinectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib may reduce lurbinectedin exposure by inducing CYP3A4, potentially reducing antitumor efficacy.
How serious is the interaction between Lorlatinib and Lurbinectedin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination if feasible and monitor tumor response.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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