Drug interactions
Lorlatinib + Naldemedine
Severity: Moderate
Lorlatinib and Naldemedine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naldemedine is a CYP3A4 substrate, so lorlatinib may lower its levels and reduce relief of opioid-induced constipation.
What this interaction means in plain words
Lorlatinib and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
Lorlatinib induces CYP3A4, increasing naldemedine metabolism.
What to do
Monitor bowel function and response to naldemedine. Consider an alternative laxative if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Lorlatinib with Naldemedine?
MediHelp rates the interaction as moderate. Lorlatinib and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naldemedine is a CYP3A4 substrate, so lorlatinib may lower its levels and reduce relief of opioid-induced constipation.
How serious is the interaction between Lorlatinib and Naldemedine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and response to naldemedine. Consider an alternative laxative if efficacy is lost.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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