Drug interactions
Lorlatinib + Naloxegol
Severity: Moderate
Lorlatinib and Naloxegol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naloxegol is a CYP3A4 and P-gp substrate, and inducers can reduce its exposure. Lorlatinib may weaken its effect on opioid-induced constipation.
What this interaction means in plain words
Lorlatinib and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Naloxegol belongs to Gastrointestinal Tract.
Why it happens
Lorlatinib induces CYP3A4, increasing naloxegol clearance.
What to do
Monitor bowel function and consider another laxative strategy if the response is lost. Avoid strong inducers per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Lorlatinib with Naloxegol?
MediHelp rates the interaction as moderate. Lorlatinib and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naloxegol is a CYP3A4 and P-gp substrate, and inducers can reduce its exposure. Lorlatinib may weaken its effect on opioid-induced constipation.
How serious is the interaction between Lorlatinib and Naloxegol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and consider another laxative strategy if the response is lost. Avoid strong inducers per labeling.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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