Drug interactions
Lorlatinib + Oliceridine
Severity: Moderate
Lorlatinib and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is cleared by CYP3A4 and CYP2D6, so lorlatinib may lower its levels and analgesic effect. Stopping lorlatinib later could raise levels and cause respiratory depression.
What this interaction means in plain words
Lorlatinib and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Oliceridine belongs to Musculoskeletal.
Why it happens
Lorlatinib induces CYP3A4, increasing oliceridine clearance.
What to do
Titrate oliceridine to analgesic effect and watch for withdrawal or inadequate pain control. Reduce the dose and monitor respiration if lorlatinib is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Lorlatinib with Oliceridine?
MediHelp rates the interaction as moderate. Lorlatinib and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oliceridine is cleared by CYP3A4 and CYP2D6, so lorlatinib may lower its levels and analgesic effect. Stopping lorlatinib later could raise levels and cause respiratory depression.
How serious is the interaction between Lorlatinib and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate oliceridine to analgesic effect and watch for withdrawal or inadequate pain control. Reduce the dose and monitor respiration if lorlatinib is discontinued.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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