Drug interactions
Lorlatinib + Pexidartinib
Severity: Moderate
Lorlatinib and Pexidartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib is a CYP3A4 substrate, and lorlatinib can induce CYP3A4 and lower pexidartinib levels. Both drugs also carry hepatotoxicity risk, so combined use needs care.
What this interaction means in plain words
Lorlatinib and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Pexidartinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing pexidartinib metabolism; additive hepatotoxic potential.
What to do
Avoid the combination if possible; if needed, monitor liver tests regularly and assess for loss of pexidartinib efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Lorlatinib with Pexidartinib?
MediHelp rates the interaction as moderate. Lorlatinib and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib is a CYP3A4 substrate, and lorlatinib can induce CYP3A4 and lower pexidartinib levels. Both drugs also carry hepatotoxicity risk, so combined use needs care.
How serious is the interaction between Lorlatinib and Pexidartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if needed, monitor liver tests regularly and assess for loss of pexidartinib efficacy.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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