Drug interactions
Lorlatinib + Riociguat
Severity: Moderate
Lorlatinib and Riociguat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Riociguat is cleared by CYP1A1, CYP3A4, CYP2C8 and CYP2J2, so lorlatinib may reduce its exposure. Efficacy in pulmonary hypertension may fall.
What this interaction means in plain words
Lorlatinib and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Riociguat belongs to Cardiovascular.
Why it happens
Lorlatinib induces CYP3A4, increasing riociguat metabolism.
What to do
Monitor clinical status and blood pressure and adjust the riociguat dose to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Lorlatinib with Riociguat?
MediHelp rates the interaction as moderate. Lorlatinib and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Riociguat is cleared by CYP1A1, CYP3A4, CYP2C8 and CYP2J2, so lorlatinib may reduce its exposure. Efficacy in pulmonary hypertension may fall.
How serious is the interaction between Lorlatinib and Riociguat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical status and blood pressure and adjust the riociguat dose to response.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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