Drug interactions
Lorlatinib + Sufentanil
Severity: Moderate
Lorlatinib and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is metabolized mainly by CYP3A4, so lorlatinib may lower its levels and analgesic effect. If lorlatinib is stopped, sufentanil levels may rise and increase respiratory depression risk.
What this interaction means in plain words
Lorlatinib and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Sufentanil belongs to Musculoskeletal.
Why it happens
Lorlatinib induces CYP3A4, increasing sufentanil clearance.
What to do
Titrate sufentanil to effect and monitor analgesia. Watch for respiratory depression and reduce the dose if lorlatinib is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Lorlatinib with Sufentanil?
MediHelp rates the interaction as moderate. Lorlatinib and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is metabolized mainly by CYP3A4, so lorlatinib may lower its levels and analgesic effect. If lorlatinib is stopped, sufentanil levels may rise and increase respiratory depression risk.
How serious is the interaction between Lorlatinib and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sufentanil to effect and monitor analgesia. Watch for respiratory depression and reduce the dose if lorlatinib is discontinued.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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