Drug interactions
Lorlatinib + Terbinafine
Severity: Minor
Lorlatinib and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate CYP3A4 inducer and could lower terbinafine levels, although terbinafine is cleared by several enzymes. The effect is likely small, but antifungal response may be reduced.
What this interaction means in plain words
Lorlatinib and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lorlatinib belongs to Oncology; Terbinafine belongs to Anti Fungals.
Why it happens
Lorlatinib induces CYP3A4, which contributes to terbinafine metabolism.
What to do
No dose change is needed; monitor antifungal efficacy and extend therapy if response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Terbinafine?
MediHelp rates the interaction as minor. Lorlatinib and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lorlatinib is a moderate CYP3A4 inducer and could lower terbinafine levels, although terbinafine is cleared by several enzymes. The effect is likely small, but antifungal response may be reduced.
How serious is the interaction between Lorlatinib and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor antifungal efficacy and extend therapy if response is inadequate.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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