Drug interactions
Lorlatinib + Tivozanib
Severity: Moderate
Lorlatinib and Tivozanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib may reduce tivozanib exposure, potentially compromising its anticancer effect.
What this interaction means in plain words
Lorlatinib and Tivozanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Tivozanib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing metabolism of tivozanib, which is partly cleared by CYP3A4.
What to do
Monitor tumor response. Avoid the combination if a suitable alternative exists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Tivozanib
- Amobarbital + Tivozanib Major
- Carbamazepine + Tivozanib Major
- Phenytoin + Tivozanib Major
- Secobarbital + Tivozanib Major
- Apalutamide + Tivozanib Moderate
- Bosentan + Tivozanib Moderate
Frequently asked questions
Can I take Lorlatinib with Tivozanib?
MediHelp rates the interaction as moderate. Lorlatinib and Tivozanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib may reduce tivozanib exposure, potentially compromising its anticancer effect.
How serious is the interaction between Lorlatinib and Tivozanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response. Avoid the combination if a suitable alternative exists.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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