Drug interactions
Lorlatinib + Voclosporin
Severity: Major
Lorlatinib and Voclosporin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A4, which is the main metabolic route of voclosporin. Lower voclosporin exposure may reduce its efficacy in lupus nephritis. Labeling advises against moderate or strong CYP3A4 inducers with voclosporin.
What this interaction means in plain words
Lorlatinib and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lorlatinib belongs to Oncology; Voclosporin belongs to Miscellaneous.
Why it happens
Lorlatinib induces CYP3A4 and increases the metabolism of voclosporin.
What to do
Avoid the combination where possible and consider a different treatment. If it cannot be avoided, monitor renal function and disease activity closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Lorlatinib with Voclosporin?
MediHelp rates the interaction as major. Lorlatinib and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lorlatinib induces CYP3A4, which is the main metabolic route of voclosporin. Lower voclosporin exposure may reduce its efficacy in lupus nephritis. Labeling advises against moderate or strong CYP3A4 inducers with voclosporin.
How serious is the interaction between Lorlatinib and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and consider a different treatment. If it cannot be avoided, monitor renal function and disease activity closely.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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