Drug interactions
Lorlatinib + Vonoprazan
Severity: Moderate
Lorlatinib and Vonoprazan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan is cleared largely by CYP3A4, and lorlatinib induces this enzyme. Lower vonoprazan concentrations could lead to reduced acid suppression and therapeutic failure.
What this interaction means in plain words
Lorlatinib and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Lorlatinib induces CYP3A4 and raises the metabolic clearance of vonoprazan.
What to do
Monitor for inadequate acid suppression and symptoms. Consider an alternative acid suppressant or a dose adjustment per product labeling if response is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Lorlatinib with Vonoprazan?
MediHelp rates the interaction as moderate. Lorlatinib and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vonoprazan is cleared largely by CYP3A4, and lorlatinib induces this enzyme. Lower vonoprazan concentrations could lead to reduced acid suppression and therapeutic failure.
How serious is the interaction between Lorlatinib and Vonoprazan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for inadequate acid suppression and symptoms. Consider an alternative acid suppressant or a dose adjustment per product labeling if response is poor.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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