Drug interactions
Lormetazepam + Meperidine
Severity: Major
Lormetazepam and Meperidine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent opioid and benzodiazepine hypnotic use raises the risk of profound sedation, respiratory depression, coma and death.
What this interaction means in plain words
Lormetazepam and Meperidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression via opioid receptors and GABA-A potentiation.
What to do
Avoid or limit to cases without alternatives, with the lowest effective doses and shortest duration. Monitor sedation and respiratory function, especially in older or frail patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Lormetazepam with Meperidine?
MediHelp rates the interaction as major. Lormetazepam and Meperidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent opioid and benzodiazepine hypnotic use raises the risk of profound sedation, respiratory depression, coma and death.
How serious is the interaction between Lormetazepam and Meperidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or limit to cases without alternatives, with the lowest effective doses and shortest duration. Monitor sedation and respiratory function, especially in older or frail patients.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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