Drug interactions
Lornoxicam + Perindopril
Severity: Moderate
Lornoxicam and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lornoxicam may reduce the antihypertensive effect of perindopril. The combination also increases the risk of acute kidney injury and hyperkalemia, especially in the elderly or dehydrated.
What this interaction means in plain words
Lornoxicam and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lornoxicam belongs to Musculoskeletal; Perindopril belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium retention and reduced renal blood flow, opposing ACE inhibitor effects.
What to do
Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Use the lowest effective lornoxicam dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Lornoxicam with Perindopril?
MediHelp rates the interaction as moderate. Lornoxicam and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lornoxicam may reduce the antihypertensive effect of perindopril. The combination also increases the risk of acute kidney injury and hyperkalemia, especially in the elderly or dehydrated.
How serious is the interaction between Lornoxicam and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Use the lowest effective lornoxicam dose for the shortest duration.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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