Drug interactions
Lornoxicam + Prazosin
Severity: Minor
Lornoxicam and Prazosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as lornoxicam can blunt the blood pressure lowering effect of antihypertensives through sodium and fluid retention. The effect on prazosin is generally modest but may reduce blood pressure control.
What this interaction means in plain words
Lornoxicam and Prazosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lornoxicam belongs to Musculoskeletal; Prazosin belongs to Genitourinary.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and water retention and vasoconstriction, opposing the vasodilating effect of prazosin.
What to do
Monitor blood pressure when an NSAID is started or used regularly with prazosin. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lornoxicam and Prazosin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Lornoxicam with Prazosin?
MediHelp rates the interaction as minor. Lornoxicam and Prazosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs such as lornoxicam can blunt the blood pressure lowering effect of antihypertensives through sodium and fluid retention. The effect on prazosin is generally modest but may reduce blood pressure control.
How serious is the interaction between Lornoxicam and Prazosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when an NSAID is started or used regularly with prazosin. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Prazosin?
MediHelp also lists interactions of Prazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Prazosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
