Drug interactions
Lornoxicam + Telmisartan
Severity: Moderate
Lornoxicam and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as lornoxicam reduce renal prostaglandin synthesis, which can blunt the antihypertensive effect of telmisartan and impair kidney function. The combination can also raise serum potassium and increases the risk of acute kidney injury, especially with dehydration, older age or diuretic use.
What this interaction means in plain words
Lornoxicam and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lornoxicam belongs to Musculoskeletal; Telmisartan belongs to Cardiovascular.
Why it happens
NSAID inhibition of prostaglandin-mediated renal vasodilation combined with ARB-induced efferent arteriolar dilation reduces glomerular filtration and potassium excretion.
What to do
Use the lowest effective NSAID dose for the shortest time, ensure adequate hydration and monitor blood pressure, creatinine and potassium. Consider an alternative analgesic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Lornoxicam with Telmisartan?
MediHelp rates the interaction as moderate. Lornoxicam and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as lornoxicam reduce renal prostaglandin synthesis, which can blunt the antihypertensive effect of telmisartan and impair kidney function. The combination can also raise serum potassium and increases the risk of acute kidney injury, especially with dehydration, older age or diuretic use.
How serious is the interaction between Lornoxicam and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time, ensure adequate hydration and monitor blood pressure, creatinine and potassium. Consider an alternative analgesic in high-risk patients.
What other medicines interact with Telmisartan?
MediHelp also lists interactions of Telmisartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan page.
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