Drug interactions
Lornoxicam + Venlafaxine
Severity: Moderate
Lornoxicam and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as lornoxicam impair platelet function and injure the gastric mucosa, while venlafaxine reduces platelet serotonin uptake. Together they markedly raise the risk of gastrointestinal bleeding.
What this interaction means in plain words
Lornoxicam and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lornoxicam belongs to Musculoskeletal; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive platelet dysfunction from SNRI-induced serotonin depletion and NSAID cyclooxygenase inhibition, plus NSAID mucosal injury.
What to do
Use the lowest effective NSAID dose for the shortest time and consider a proton pump inhibitor in higher-risk patients. Advise patients to report black stools, vomiting blood or abdominal pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Lornoxicam
Frequently asked questions
Can I take Lornoxicam with Venlafaxine?
MediHelp rates the interaction as moderate. Lornoxicam and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as lornoxicam impair platelet function and injure the gastric mucosa, while venlafaxine reduces platelet serotonin uptake. Together they markedly raise the risk of gastrointestinal bleeding.
How serious is the interaction between Lornoxicam and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and consider a proton pump inhibitor in higher-risk patients. Advise patients to report black stools, vomiting blood or abdominal pain.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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