Drug interactions
Losartan + Meclofenamate
Severity: Moderate
Losartan and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive effect of losartan and, when combined with an angiotensin receptor blocker, raise the risk of acute kidney injury, especially in older patients or those who are volume depleted. Potassium may also rise.
What this interaction means in plain words
Losartan and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium and fluid retention and reduces glomerular perfusion, which counteracts angiotensin receptor blockade and impairs renal function.
What to do
Avoid regular NSAID use where possible; if needed, ensure hydration and monitor blood pressure, serum creatinine and potassium after starting and periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Meclofenamate?
MediHelp rates the interaction as moderate. Losartan and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive effect of losartan and, when combined with an angiotensin receptor blocker, raise the risk of acute kidney injury, especially in older patients or those who are volume depleted. Potassium may also rise.
How serious is the interaction between Losartan and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible; if needed, ensure hydration and monitor blood pressure, serum creatinine and potassium after starting and periodically.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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