Drug interactions
Losartan + Methyclothiazide
Severity: Minor
Losartan and Methyclothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics are commonly combined with losartan for additive blood pressure lowering. The ARB tends to offset thiazide-induced potassium loss, but excessive volume depletion can cause hypotension or renal impairment.
What this interaction means in plain words
Losartan and Methyclothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Complementary pharmacodynamic effects: diuresis and natriuresis with renin-angiotensin blockade, and opposing effects on potassium.
What to do
Monitor blood pressure, electrolytes and renal function when starting or adjusting either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Methyclothiazide?
MediHelp rates the interaction as minor. Losartan and Methyclothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics are commonly combined with losartan for additive blood pressure lowering. The ARB tends to offset thiazide-induced potassium loss, but excessive volume depletion can cause hypotension or renal impairment.
How serious is the interaction between Losartan and Methyclothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, electrolytes and renal function when starting or adjusting either drug.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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