Drug interactions
Losartan + Mipomersen
Severity: Minor
Losartan and Mipomersen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen is associated with hepatotoxicity and raised transaminases, and losartan can rarely cause liver enzyme elevations. Combined use may add to hepatic monitoring concerns, although a true interaction is not well documented.
What this interaction means in plain words
Losartan and Mipomersen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive hepatotoxicity; no pharmacokinetic mechanism established.
What to do
Follow the mipomersen liver enzyme monitoring schedule and investigate any transaminase rise before attributing it to either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Mipomersen?
MediHelp rates the interaction as minor. Losartan and Mipomersen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mipomersen is associated with hepatotoxicity and raised transaminases, and losartan can rarely cause liver enzyme elevations. Combined use may add to hepatic monitoring concerns, although a true interaction is not well documented.
How serious is the interaction between Losartan and Mipomersen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow the mipomersen liver enzyme monitoring schedule and investigate any transaminase rise before attributing it to either drug.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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