Drug interactions
Losartan + Nafcillin
Severity: Minor
Losartan and Nafcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin has enzyme-inducing properties and may lower losartan exposure, possibly reducing blood pressure control during treatment. The effect is mainly documented with other CYP substrates and is likely modest for losartan.
What this interaction means in plain words
Losartan and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible induction of hepatic CYP enzymes that metabolize losartan.
What to do
Monitor blood pressure during nafcillin courses and after discontinuation, adjusting losartan if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Nafcillin?
MediHelp rates the interaction as minor. Losartan and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin has enzyme-inducing properties and may lower losartan exposure, possibly reducing blood pressure control during treatment. The effect is mainly documented with other CYP substrates and is likely modest for losartan.
How serious is the interaction between Losartan and Nafcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during nafcillin courses and after discontinuation, adjusting losartan if needed.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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