Drug interactions
Losartan + Nefazodone
Severity: Minor
Losartan and Nefazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone strongly inhibits CYP3A4, which contributes to losartan metabolism, so losartan levels might rise while formation of the active metabolite could fall. Net clinical effect is uncertain and probably small.
What this interaction means in plain words
Losartan and Nefazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 inhibition by nefazodone altering losartan metabolism.
What to do
Monitor blood pressure when nefazodone is started or stopped and adjust losartan if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Nefazodone?
MediHelp rates the interaction as minor. Losartan and Nefazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nefazodone strongly inhibits CYP3A4, which contributes to losartan metabolism, so losartan levels might rise while formation of the active metabolite could fall. Net clinical effect is uncertain and probably small.
How serious is the interaction between Losartan and Nefazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when nefazodone is started or stopped and adjust losartan if needed.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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