Drug interactions
Losartan + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Moderate
Losartan and Ombitasvir / paritaprevir / ritonavir and dasabuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The ritonavir-boosted regimen inhibits CYP3A4 and other pathways and may alter losartan exposure, with hypotension or renal function changes reported with ARBs in this setting. Paritaprevir also inhibits OATP transporters.
What this interaction means in plain words
Losartan and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 and transporters by ritonavir and paritaprevir increasing ARB exposure.
What to do
Consider reducing the losartan dose and monitor blood pressure and renal function during the antiviral course; reduce further or switch if hypotension or renal worsening occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as moderate. Losartan and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The ritonavir-boosted regimen inhibits CYP3A4 and other pathways and may alter losartan exposure, with hypotension or renal function changes reported with ARBs in this setting. Paritaprevir also inhibits OATP transporters.
How serious is the interaction between Losartan and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the losartan dose and monitor blood pressure and renal function during the antiviral course; reduce further or switch if hypotension or renal worsening occurs.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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