Drug interactions
Losartan + Parecoxib
Severity: Moderate
Losartan and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
As with other NSAIDs, parecoxib can reduce the antihypertensive effect of losartan and, in combination with an ARB, increase the risk of acute kidney injury and hyperkalemia. Older or volume-depleted patients are at highest risk.
What this interaction means in plain words
Losartan and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reducing renal perfusion, causing sodium retention and impairing potassium excretion.
What to do
Use the lowest effective parecoxib dose for the shortest time, keep the patient hydrated, and monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Parecoxib?
MediHelp rates the interaction as moderate. Losartan and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. As with other NSAIDs, parecoxib can reduce the antihypertensive effect of losartan and, in combination with an ARB, increase the risk of acute kidney injury and hyperkalemia. Older or volume-depleted patients are at highest risk.
How serious is the interaction between Losartan and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective parecoxib dose for the shortest time, keep the patient hydrated, and monitor blood pressure, creatinine and potassium.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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