Drug interactions
Losartan + Penbutolol
Severity: Minor
Losartan and Penbutolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta blockers and ARBs are often used together and give additive blood pressure lowering, which may cause excessive hypotension or bradycardia. Beta blockers can also slightly raise potassium. The pregnancy concern relates to losartan itself rather than to the combination.
What this interaction means in plain words
Losartan and Penbutolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antihypertensive effects through beta-adrenergic blockade and renin-angiotensin blockade.
What to do
Monitor blood pressure and heart rate when starting or titrating either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Penbutolol?
MediHelp rates the interaction as minor. Losartan and Penbutolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Beta blockers and ARBs are often used together and give additive blood pressure lowering, which may cause excessive hypotension or bradycardia. Beta blockers can also slightly raise potassium. The pregnancy concern relates to losartan itself rather than to the combination.
How serious is the interaction between Losartan and Penbutolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or titrating either drug.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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