Drug interactions
Losartan + Pentobarbital
Severity: Minor
Losartan and Pentobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital may induce hepatic enzymes and lower exposure to losartan and its active metabolite. Blood pressure control could be modestly reduced during prolonged barbiturate use, and the effect is unlikely to matter with brief exposure.
What this interaction means in plain words
Losartan and Pentobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate induction of hepatic CYP enzymes, including CYP2C9 and CYP3A4, increasing metabolic clearance of losartan.
What to do
Monitor blood pressure if pentobarbital is used regularly and increase the losartan dose if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Pentobarbital?
MediHelp rates the interaction as minor. Losartan and Pentobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pentobarbital may induce hepatic enzymes and lower exposure to losartan and its active metabolite. Blood pressure control could be modestly reduced during prolonged barbiturate use, and the effect is unlikely to matter with brief exposure.
How serious is the interaction between Losartan and Pentobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if pentobarbital is used regularly and increase the losartan dose if control is lost.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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