Drug interactions
Losartan + Potassium citrate-citric acid
Severity: Moderate
Losartan and Potassium citrate-citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Losartan reduces aldosterone-mediated potassium excretion, so potassium citrate can lead to hyperkalemia. Risk is higher with kidney disease, diabetes or older age.
What this interaction means in plain words
Losartan and Potassium citrate-citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Losartan belongs to Cardiovascular; Potassium citrate-citric acid belongs to Gastrointestinal Tract.
Why it happens
Angiotensin II receptor blockade reduces renal potassium excretion, adding to the potassium load.
What to do
Check serum potassium and creatinine before and soon after starting the combination, then periodically. Reduce or stop the potassium salt if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Potassium citrate-citric acid
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Potassium citrate-citric acid?
MediHelp rates the interaction as moderate. Losartan and Potassium citrate-citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Losartan reduces aldosterone-mediated potassium excretion, so potassium citrate can lead to hyperkalemia. Risk is higher with kidney disease, diabetes or older age.
How serious is the interaction between Losartan and Potassium citrate-citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and creatinine before and soon after starting the combination, then periodically. Reduce or stop the potassium salt if potassium rises.
What other medicines interact with Potassium citrate-citric acid?
MediHelp also lists interactions of Potassium citrate-citric acid with, for example, Amiloride, Eplerenone, Finerenone. The full list is on the Potassium citrate-citric acid page.
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