Drug interactions
Losartan + Potassium citrate / citric acid
Severity: Moderate
Losartan and Potassium citrate / citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Losartan reduces aldosterone-mediated potassium excretion, and potassium citrate adds a potassium load. This can cause hyperkalemia, especially in patients with renal impairment or diabetes.
What this interaction means in plain words
Losartan and Potassium citrate / citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive increases in serum potassium from reduced renal potassium excretion and potassium supplementation.
What to do
Check serum potassium and renal function at baseline and periodically. Reduce or stop the potassium supplement if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Potassium citrate / citric acid?
MediHelp rates the interaction as moderate. Losartan and Potassium citrate / citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Losartan reduces aldosterone-mediated potassium excretion, and potassium citrate adds a potassium load. This can cause hyperkalemia, especially in patients with renal impairment or diabetes.
How serious is the interaction between Losartan and Potassium citrate / citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function at baseline and periodically. Reduce or stop the potassium supplement if potassium rises.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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