Drug interactions
Losartan + Quinapril
Severity: Major
Losartan and Quinapril: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an ARB with an ACE inhibitor gives dual renin-angiotensin system blockade. It increases the risk of hypotension, hyperkalemia and acute kidney injury without clear added benefit in most patients.
What this interaction means in plain words
Losartan and Quinapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic inhibition of the renin-angiotensin-aldosterone system at two sites.
What to do
Avoid routine combination; if used under specialist direction, monitor blood pressure, potassium and creatinine closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Quinapril?
MediHelp rates the interaction as major. Losartan and Quinapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an ARB with an ACE inhibitor gives dual renin-angiotensin system blockade. It increases the risk of hypotension, hyperkalemia and acute kidney injury without clear added benefit in most patients.
How serious is the interaction between Losartan and Quinapril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination; if used under specialist direction, monitor blood pressure, potassium and creatinine closely.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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