Drug interactions
Losartan + Sodium sulfate / potassium sulfate / magnesium sulfate
Severity: Moderate
Losartan and Sodium sulfate / potassium sulfate / magnesium sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfate bowel preparations cause fluid loss and electrolyte shifts. With losartan, volume depletion can raise the risk of acute kidney injury and hypotension.
What this interaction means in plain words
Losartan and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bowel-prep-induced volume depletion and electrolyte shifts add to ARB-mediated reduction of glomerular filtration pressure.
What to do
Maintain adequate hydration and consider holding losartan on the day of preparation in patients at risk of kidney injury. Check renal function and electrolytes if symptoms of volume depletion occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates the interaction as moderate. Losartan and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfate bowel preparations cause fluid loss and electrolyte shifts. With losartan, volume depletion can raise the risk of acute kidney injury and hypotension.
How serious is the interaction between Losartan and Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain adequate hydration and consider holding losartan on the day of preparation in patients at risk of kidney injury. Check renal function and electrolytes if symptoms of volume depletion occur.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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