Drug interactions
Losartan + Synthetic human angiotensin ii
Severity: Moderate
Losartan and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Losartan blocks AT1 receptors, so it can blunt the pressor response to exogenous angiotensin II. In patients receiving angiotensin II for vasodilatory shock, prior ARB therapy may reduce its effectiveness and higher doses may be needed.
What this interaction means in plain words
Losartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competitive antagonism of angiotensin II type 1 receptors by losartan.
What to do
Titrate angiotensin II to blood pressure response and expect higher requirements in patients on ARBs. Hold ARBs during shock.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Losartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Losartan blocks AT1 receptors, so it can blunt the pressor response to exogenous angiotensin II. In patients receiving angiotensin II for vasodilatory shock, prior ARB therapy may reduce its effectiveness and higher doses may be needed.
How serious is the interaction between Losartan and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate angiotensin II to blood pressure response and expect higher requirements in patients on ARBs. Hold ARBs during shock.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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