Drug interactions
Losartan + Xipamide
Severity: Minor
Losartan and Xipamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic, and combining it with losartan produces additive blood pressure lowering, which is often intended. First-dose hypotension, volume depletion and renal function changes can occur, though losartan may offset diuretic-induced hypokalemia.
What this interaction means in plain words
Losartan and Xipamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Complementary antihypertensive actions: diuretic-induced volume and sodium loss plus AT1 receptor blockade.
What to do
Monitor blood pressure, electrolytes and renal function when starting or adjusting either drug. Lower the diuretic dose initially if the patient is volume depleted.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Xipamide?
MediHelp rates the interaction as minor. Losartan and Xipamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Xipamide is a thiazide-like diuretic, and combining it with losartan produces additive blood pressure lowering, which is often intended. First-dose hypotension, volume depletion and renal function changes can occur, though losartan may offset diuretic-induced hypokalemia.
How serious is the interaction between Losartan and Xipamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, electrolytes and renal function when starting or adjusting either drug. Lower the diuretic dose initially if the patient is volume depleted.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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