Drug interactions
Lovastatin + Lumefantrine
Severity: Minor
Lovastatin and Lumefantrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine has little established effect on lovastatin, and any CYP3A4 effect would be small and short-lived during a brief antimalarial course. No clinically meaningful interaction is established.
What this interaction means in plain words
Lovastatin and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 modulation; the mechanism is not well established.
What to do
No action is needed beyond awareness; monitor for the usual statin adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Lovastatin with Lumefantrine?
MediHelp rates the interaction as minor. Lovastatin and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine has little established effect on lovastatin, and any CYP3A4 effect would be small and short-lived during a brief antimalarial course. No clinically meaningful interaction is established.
How serious is the interaction between Lovastatin and Lumefantrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond awareness; monitor for the usual statin adverse effects.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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