Drug interactions
Lovastatin + Miconazole vaginal
Severity: Minor
Lovastatin and Miconazole vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaginal miconazole has limited systemic absorption, but case reports of interactions with other drugs exist, so a small rise in lovastatin exposure is conceivable. Oral azoles are the main concern; the vaginal route is generally low risk.
What this interaction means in plain words
Lovastatin and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 inhibition by absorbed miconazole.
What to do
No routine change; for prolonged or repeated courses, advise the patient to report muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Lovastatin with Miconazole vaginal?
MediHelp rates the interaction as minor. Lovastatin and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vaginal miconazole has limited systemic absorption, but case reports of interactions with other drugs exist, so a small rise in lovastatin exposure is conceivable. Oral azoles are the main concern; the vaginal route is generally low risk.
How serious is the interaction between Lovastatin and Miconazole vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change; for prolonged or repeated courses, advise the patient to report muscle pain or weakness.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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