Drug interactions
Lovastatin + Nafcillin
Severity: Minor
Lovastatin and Nafcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin induces CYP3A4 and may reduce lovastatin concentrations, weakening its lipid-lowering effect. This is an efficacy issue rather than a safety hazard and usually matters little during a short antibiotic course.
What this interaction means in plain words
Lovastatin and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 induction by nafcillin increases lovastatin metabolism.
What to do
No action for short courses; recheck lipids if nafcillin is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Lovastatin with Nafcillin?
MediHelp rates the interaction as minor. Lovastatin and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin induces CYP3A4 and may reduce lovastatin concentrations, weakening its lipid-lowering effect. This is an efficacy issue rather than a safety hazard and usually matters little during a short antibiotic course.
How serious is the interaction between Lovastatin and Nafcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action for short courses; recheck lipids if nafcillin is prolonged.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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